Identification of human cell responses to benzene and benzene metabolites
نویسندگان
چکیده
منابع مشابه
Characterization of micronuclei induced in human lymphocytes by benzene metabolites.
Benzene is an established human leukemogen. Workers occupationally exposed to benzene exhibit increased frequencies of both structural and numerical chromosomal aberrations in their peripheral blood lymphocytes. The metabolite(s) responsible for these chromosomal aberrations has not yet been identified. Using a modified micronucleus assay, we have examined the ability of the metabolites of benz...
متن کاملAlbumin Adducts of Electrophilic Benzene Metabolites in Benzene-Exposed and Control Workers
BACKGROUND Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts. OBJECTIVES The main purpose of this study was to characterize relationships between levels of albumin adducts of these electrophiles in blood and the corresponding benzene ...
متن کاملBenzene toxicokinetics in humans: exposure of bone marrow to metabolites.
A three compartment physiologically based toxicokinetic model was fitted to human data on benzene disposition. Two separate groups of model parameter derivations were obtained, depending on which data sets were being fitted. The model was then used to simulate five environmental or occupational exposures. Predicted values of the total bone marrow exposure to benzene and cumulative quantity of m...
متن کاملAn interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure.
Benzene-induced myelotoxicity can be reproduced by the coadministration of two principal metabolites, phenol and hydroquinone. Coadministration of phenol (75 mg/kg) and hydroquinone (25-75 mg/kg) twice daily to B6C3F1 mice for 12 days resulted in a significant loss in bone marrow cellularity in a manner exhibiting a dose-response. One explanation for this potentiation is that phenol stimulates ...
متن کاملNon-linear production of benzene oxide-albumin adducts with human exposure to benzene.
Benzene is initially metabolized to benzene oxide, which either undergoes further metabolism or reacts with macromolecules including proteins. Previously reported levels of benzene oxide-albumin adducts (BO-Alb) are analyzed from 30 workers exposed to 0.2-302 ppm benzene and 43 controls from Shanghai, China. Although both exposed workers and controls had significant levels of BO-Alb in their bl...
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ژورنال
عنوان ژورنال: Genomics
سال: 2007
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2007.05.003